To date, no variants of high consequence have been identified in the United States.Additional Variants Being Monitored include Epsilon (B.1.427 and B.1.429) and Zeta (P.2) based on their previous classification as Variants of Concern or Variants of Interest.Eta (B.1.525), Iota (B.1.526), Kappa (B.1.617.1), and B.1.617.3 have been downgraded from Variants of Interest to Variants Being Monitored based on significant and sustained reduction in national and regional proportions.Alpha (B.1.1.7, Q.1-Q.8), Beta (B.1.351, B.1.351.2, B.1.351.3), and Gamma (P.1, P.1.1, P.1.2) have been downgraded from Variants of Concern to Variants Being Monitored based on significant and sustained reduction in national and regional proportions.The SIG Variant classification scheme defines four classes of SARS-CoV-2 variants:.This class includes variants with substitutions of concern, including previously designated Variants of Interest (VOIs) or Variants of Concern (VOCs), that are no longer detected or are circulating at very low levels in the United States, and as such, do not pose a significant or imminent risk to public health in the United States.The US government SARS-CoV-2 Interagency Group (SIG) added a new class of SARS-CoV-2 variants designated as Variants Being Monitored.SARS-CoV-2 genetic lineages in the United States are routinely monitored through epidemiological investigations, virus genetic sequence-based surveillance, and laboratory studies.Genetic lineages of SARS-CoV-2 have been emerging and circulating around the world since the beginning of the COVID-19 pandemic.

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